Publicação
Mutation ‘C11994T’ in the mitochondrial ND4 gene is not a cause of low sperm motility in Portugal
| Resumo: | It has recently been suggested that a hitherto unobserved mutation, C11994T, causes oligoasthenozoospermia in men from India but at the same time does not affect systems other than the motility of the sperm. There are good reasons to question this proposition, in view of the worldwide mtDNA database and the Indian record in particular. We have further analyzed the oligoasthenozoospermic samples from a previous systematic study of infertile Portuguese men and found no instance of C11994T. |
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| Autores principais: | Pereira, L |
| Outros Autores: | Gonçalves, J; Bandelt, H-J |
| Assunto: | Asthenozoospermia/enzymology Asthenozoospermia/genetics Asthenozoospermia/physiopathology DNA Mitochondrial Genotype Haplotypes Humans Male Mitochondria/enzymology Mutation NADH Dehydrogenase/genetics Oligospermia Phenotype Portugal Sperm Motility/genetics Spermatozoa/enzymology |
| Ano: | 2008 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Porto |
| Idioma: | inglês |
| Origem: | Repositório Aberto da Universidade do Porto |
| Resumo: | It has recently been suggested that a hitherto unobserved mutation, C11994T, causes oligoasthenozoospermia in men from India but at the same time does not affect systems other than the motility of the sperm. There are good reasons to question this proposition, in view of the worldwide mtDNA database and the Indian record in particular. We have further analyzed the oligoasthenozoospermic samples from a previous systematic study of infertile Portuguese men and found no instance of C11994T. |
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