Detalhes bibliográficos
| Resumo: | We report a 63-year-old man with well-controlled type 2 diabetes mellitus and hypertension, who presented with new onset nephrotic proteinuria and rapid deterioration in renal function. The atypical clinical presentation prompted us to consider a non-diabetic and non-hypertensive cause and to perform a renal biopsy. A diagnosis of fibrillarglomerulonephritis (FGn) was made based on electronic microscopy. Proteinuria remained in nephrotic range despite treatment with prednisolone, and renal function deteriorated. We suggest that other causes of proteinuria should be considered in patients with diabetes who present with the nephrotic syndrome when there is no other evidence of microvascular disease. We review the spectrum of fibrillar glomerulopathies including FGn, primary and secondary amyloidosis and immunotactoid glomerulonephritis. |
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| Autores principais: | Azevedo, A |
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| Outros Autores: | Cotovio, P; Góis, M; Nolasco, F |
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| Assunto: | HCC NEF Male Humans Middle Aged Amyloidosis / diagnosis Biopsy / methods Diabetes Mellitus, Type 2 / complications Diabetes Mellitus, Type 2 / epidemiology Glomerulonephritis / pathology* Glucocorticoids / therapeutic use Nephrotic Syndrome / diagnosis* Nephrotic Syndrome / etiology Nephrotic Syndrome / pathology Prednisolone / administration & dosage Prednisolone / therapeutic use Proteinuria / diagnosis* Proteinuria / etiology Rare Diseases Treatment Outcome Vascular Access Devices / standards |
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| Ano: | 2019 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Centro Hospitalar de Lisboa Central, EPE (CHLC) |
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| Idioma: | inglês |
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| Origem: | Repositório do Centro Hospitalar de Lisboa Central, EPE |
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