Detalhes bibliográficos
| Resumo: | In view of the scarcity of data to guide decision making, we evaluated how BNT162b2 and mRNA-1273 vaccines affect the immune response in lactating women and the protective profile of breastmilk. Compared with controls, lactating women had a higher frequency of circulating RBD memory B cells and higher anti-RBD antibody titers but similar neutralizing capacity. We show that upon vaccination, immune transfer to breastmilk occurs through a combination of anti-spike secretory IgA (SIgA) antibodies and spike-reactive T cells. Although we found that the concentration of anti-spike IgA in breastmilk might not be sufficient to directly neutralize SARS-CoV-2, our data suggest that cumulative transfer of IgA might provide the infant with effective neutralization capacity. Our findings put forward the possibility that breastmilk might convey both immediate (through anti-spike SIgA) and long-lived (via spike-reactive T cells) immune protection to the infant. Further studies are needed to address this possibility and to determine the functional profile of spike T cells. |
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| Autores principais: | Gonçalves, J |
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| Outros Autores: | Juliano, AM; Charepe, N; Alenquer, M; Athayde, D; Ferreira, F; Archer, M; Amorim, MJ; Serrano, F; Soares, H |
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| Assunto: | MAC MED MAF Antibodies, Viral / blood Antibodies, Viral / immunology COVID-19 / immunology COVID-19 / prevention & control COVID-19 Vaccines / immunology* Female Humans Immunity, Maternally-Acquired Immunoglobulin A, Secretory / immunology* Lactation / immunology Memory B Cells / immunology Milk, Human / immunology* SARS-CoV-2 / immunology* Spike Glycoprotein, Coronavirus / immunology* T-Lymphocytes / immunology* mRNA Vaccines / immunology Vaccination |
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| Ano: | 2021 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Centro Hospitalar de Lisboa Central, EPE (CHLC) |
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| Idioma: | inglês |
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| Origem: | Repositório do Centro Hospitalar de Lisboa Central, EPE |
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