Publicação

Validation of the Adult Asthma Epidemiological Score: a secondary analysis of EPI-ASTHMA

Detalhes bibliográficos
Resumo:	The A2 score is an 8-question patient-reported outcome measure that has been validated for ruling in (score ≥4) and ruling out (score 0-1) asthma. However, this screening tool has been validated in a cohort similar to the derivation cohort used. This study aims to validate the predictive accuracy of the A2 score in a primary care population against general practitioner (GP) clinical assessment and to determine whether the proposed cut-offs are the most appropriate. This accuracy study is a secondary analysis of the EPI-ASTHMA population-based study. Random adult participants recruited from primary healthcare centers in Portugal were analyzed. Participants answered the A2 score by telephone interview. Those with an A2 score ≥1 (plus 5% with an A2 score of 0) were invited to a diagnostic visit carried out by a GP to confirm or not a diagnosis of asthma. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) curves. A total of 1283 participants (median 54[p25-p75 43-66] years; 60% female) were analyzed. The A2 score showed high discriminatory power in identifying asthma, with an area under the ROC curve of 82.9(95%CI 80.4-85.4)%. The proposed cut-off ≥4 was the most appropriate to rule in asthma (specificity 83.1%, positive predictive value 62.4%, accuracy 78%). Similarly, the proposed cut-off <2 was the most suitable for excluding asthma (sensitivity 92.7%, negative predictive value 93.7%, accuracy 60.5%). The A2 score is a useful tool to identify patients with asthma in a primary care population.
Autores principais:	Laranjeira, Catarina
Outros Autores:	Jácome, Cristina; Amaral, Rita; Bernardo, Filipa; Correia-deSousa, Jaime; Fonseca, João A.; Amaral, Rita
Assunto:	Asthma Epidemiology Diagnostic screening Patient-reported outcome measure
Ano:	2024
País:	Portugal
Tipo de documento:	póster em conferência
Tipo de acesso:	acesso aberto
Instituição associada:	Instituto Politécnico do Porto
Idioma:	inglês
Origem:	Repositório Científico do Instituto Politécnico do Porto

Descrição
Resumo:	The A2 score is an 8-question patient-reported outcome measure that has been validated for ruling in (score ≥4) and ruling out (score 0-1) asthma. However, this screening tool has been validated in a cohort similar to the derivation cohort used. This study aims to validate the predictive accuracy of the A2 score in a primary care population against general practitioner (GP) clinical assessment and to determine whether the proposed cut-offs are the most appropriate. This accuracy study is a secondary analysis of the EPI-ASTHMA population-based study. Random adult participants recruited from primary healthcare centers in Portugal were analyzed. Participants answered the A2 score by telephone interview. Those with an A2 score ≥1 (plus 5% with an A2 score of 0) were invited to a diagnostic visit carried out by a GP to confirm or not a diagnosis of asthma. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) curves. A total of 1283 participants (median 54[p25-p75 43-66] years; 60% female) were analyzed. The A2 score showed high discriminatory power in identifying asthma, with an area under the ROC curve of 82.9(95%CI 80.4-85.4)%. The proposed cut-off ≥4 was the most appropriate to rule in asthma (specificity 83.1%, positive predictive value 62.4%, accuracy 78%). Similarly, the proposed cut-off <2 was the most suitable for excluding asthma (sensitivity 92.7%, negative predictive value 93.7%, accuracy 60.5%). The A2 score is a useful tool to identify patients with asthma in a primary care population.