Detalhes bibliográficos
| Resumo: | AIMS: Data on efavirenz in HIV/viral hepatitis co-infected patients is non-consensual, probably due to liver function heterogeneity in the patients included. METHODS: A case control study was performed on 27 HIV-infected patients, with controlled and homogenous markers of hepatic function, either mono-infected or co-infected with HBV/HCV, to ascertain the influence of viral hepatitis on efavirenz concentrations over a 2-year follow-up period. RESULTS: No differences were found in efavirenz concentrations between groups both during and at the end of the follow-up period: control (2.43 +/- 1.91 mg l(-1)) vs. co-infected individuals (2.37 +/- 0.37 mg l(-1)). CONCLUSION: It was concluded that HBV/HCV infections in themselves do not predispose to an overexposure to efavirenz. |
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| Autores principais: | Pereira, S |
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| Outros Autores: | Caixas, U; Branco, T; Germano, I; Lampreia, F; Papoila, A; Monteiro, E |
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| Assunto: | Infecção por HIV Hepatite B Hepatite C HIV infections Hepatitis B Hepatitis C Efavirenz |
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| Ano: | 2008 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Hospital Prof. Dr. Fernando Fonseca E.P.E. |
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| Idioma: | inglês |
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| Origem: | Repositório do Hospital Prof. Doutor Fernando Fonseca |
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