Publicação
Jasminum-based nano-reinforced calcium hydroxide reduces postoperative pain in symptomatic apical periodontitis: a randomized controlled trial
| Resumo: | Introduction: This study evaluated the efficacy of a novel Jasminum-based titanium dioxide nano-reinforced calcium hydroxide (Ca(OH)2) intracanal medicament in reducing postoperative pain (PP) compared to conventional Ca(OH)2 in patients with symptomatic apical periodontitis. Methods: A triple-blind randomized clinical trial, registered at ClinicalTrials.gov (NCT06653608, 10/19/2024) included patients with single-rooted teeth diagnosed with pulp necrosis and symptomatic AP. Patients referred for endodontic treatment fulfilling the inclusion criteria were included. The patients were grouped into nano-reinforced Ca(OH)2 group (n 5 30) and conventional-Ca(OH)2 (n 5 30). Preoperative pain and PP at 4, 24, 48, 72, and 96 hours were recorded using a visual analog scale. Data were analyzed using linear mixedeffects models (R software, version 4.3.2., R Core Team, Vienna, Austria), with significance set at P , .05. Results: Sixty patients with comparable demographic and clinical characteristics, including preoperative pain scores, were recruited. Both groups exhibited significant pain reduction over 96 hours (P , .001). However, a significant group-time interaction was observed (P , .001), with the nano-reinforced Ca(OH)2 group reporting consistently lower PP scores and greater reductions in PP compared to the conventional Ca(OH)2 group at all-time points. Conclusion: The incorporation of Jasminum-based TiO2 nanoparticles to Ca(OH)2 significantly improved the reduction in PP intensity and duration compared to conventional Ca(OH)2, making it a superior option for PP management. (J Endod 2025;-:1–10.) |
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| Autores principais: | Amir, Nehal |
| Outros Autores: | Mansoor, Emaan; Eeman, Nabiha; Ahmed, Muhammad Nouman; Mansoor, Ezza; Mansoor, Efrah; Hussain, Khadim; Afreixo, Vera; Mansoor, Afsheen; Brochado Martins, João Filipe; Palma, Paulo J. |
| Assunto: | Apical periodontitis Calcium hydroxide Endodontic Nanoparticles Postoperative pain |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Aveiro |
| Idioma: | inglês |
| Origem: | RIA - Repositório Institucional da Universidade de Aveiro |
| Resumo: | Introduction: This study evaluated the efficacy of a novel Jasminum-based titanium dioxide nano-reinforced calcium hydroxide (Ca(OH)2) intracanal medicament in reducing postoperative pain (PP) compared to conventional Ca(OH)2 in patients with symptomatic apical periodontitis. Methods: A triple-blind randomized clinical trial, registered at ClinicalTrials.gov (NCT06653608, 10/19/2024) included patients with single-rooted teeth diagnosed with pulp necrosis and symptomatic AP. Patients referred for endodontic treatment fulfilling the inclusion criteria were included. The patients were grouped into nano-reinforced Ca(OH)2 group (n 5 30) and conventional-Ca(OH)2 (n 5 30). Preoperative pain and PP at 4, 24, 48, 72, and 96 hours were recorded using a visual analog scale. Data were analyzed using linear mixedeffects models (R software, version 4.3.2., R Core Team, Vienna, Austria), with significance set at P , .05. Results: Sixty patients with comparable demographic and clinical characteristics, including preoperative pain scores, were recruited. Both groups exhibited significant pain reduction over 96 hours (P , .001). However, a significant group-time interaction was observed (P , .001), with the nano-reinforced Ca(OH)2 group reporting consistently lower PP scores and greater reductions in PP compared to the conventional Ca(OH)2 group at all-time points. Conclusion: The incorporation of Jasminum-based TiO2 nanoparticles to Ca(OH)2 significantly improved the reduction in PP intensity and duration compared to conventional Ca(OH)2, making it a superior option for PP management. (J Endod 2025;-:1–10.) |
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