Detalhes bibliográficos
| Resumo: | Organisms use highly accurate molecular processes to transcribe their genes and a variety of mRNA quality control and ribosome proofreading mechanisms to maintain intact the fidelity of genetic information flow. Despite this, low level gene translational errors induced by mutations and environmental factors cause neurodegeneration and premature death in mice and mitochondrial disorders in humans. Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and bacteria through poorly understood molecular processes. |
|---|
| Autores principais: | Paredes, João A. |
|---|
| Outros Autores: | Carreto, Laura; Simões, João; Bezerra, Ana R.; Gomes, Ana C.; Santamaria, Rodrigo; Kapushesky, Misha; Moura, Gabriela R.; Santos, Manuel A. S. |
|---|
| Assunto: | Yeast Mistranslation tRNA Protein synthesis mRNA profiling Stress Proteotoxic stress Protein misfolding Unfolded protein response |
|---|
| Ano: | 2012 |
|---|
| País: | Portugal |
|---|
| Tipo de documento: | artigo |
|---|
| Tipo de acesso: | acesso aberto |
|---|
| Instituição associada: | Universidade de Aveiro |
|---|
| Idioma: | inglês |
|---|
| Origem: | RIA - Repositório Institucional da Universidade de Aveiro |
|---|