Publicação
Antibacterial materials and films based on multifunctional bioglasses for implants
| Resumo: | The long-term success of orthopaedic and dental implants is often compromised by insufficient osseointegration and post-surgical infections. Although titanium alloys such as Ti6Al4V offer excellent mechanical strength and corrosion re-sistance, their limited bioactivity can lead to implant loosening, bacterial coloni-zation, and eventual failure. This thesis explores the development of bioactive glass coatings designed to address these challenges by enhancing osseointe-gration and providing antibacterial protection. Bioactive glasses based on the 45S5 Bioglass® composition were modified with varying concentrations of CuO, Nb₂O₅, ZrO₂, and Fe₃O₄ to enhance antibacterial activity and bioactivity. The incorporation of these oxides altered the glass net-work connectivity, affecting ion mobility, dissolution rates, and overall biological performance. In addition to structural and morphological characterization, the electrical properties were evaluated to assess the impact of oxide addition on charge storage capacity, which can influence the osseointegration process. Fol-lowing comprehensive structural, morphological, electrical, and biological evalu-ations, the optimal concentrations of each oxide were identified based on their cytocompatibility, bioactivity, antibacterial efficacy, and electrical properties. The optimized bioglass compositions were deposited onto Ti6Al4V metallic sub-strates using the CoBlast™ technique. This deposition method resulted in uni-form coatings with consistent microscale roughness and hydrophilic behavior, both favorable for promoting cell adhesion and proliferation. Mechanical testing confirmed the strong adhesion of the coatings to the substrates, ensuring dura-bility under physiological conditions. In vitro biological assays confirmed that all coatings supported cell adhesion and proliferation over time, while also exhibiting strong antibacterial activity, effectively reducing bacterial adhesion and biofilm formation. An enhancement in bioactivity was observed for the electrically charged coatings through the corona discharge compared to non-charged coat-ings. The findings of this thesis highlight the potential of oxide-modified bioactive glass coatings to improve implant longevity and biocompatibility, offering promising ap-plications in orthopaedic and dental fields. |
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| Autores principais: | Hammami, Imen |
| Assunto: | Implant 45S5 Bioglass Coatings CoBlast™ Antibacterial activity Osseointegra tion Antibacterial activity Electrical charging |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | tese de doutoramento |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Aveiro |
| Idioma: | inglês |
| Origem: | RIA - Repositório Institucional da Universidade de Aveiro |
| Resumo: | The long-term success of orthopaedic and dental implants is often compromised by insufficient osseointegration and post-surgical infections. Although titanium alloys such as Ti6Al4V offer excellent mechanical strength and corrosion re-sistance, their limited bioactivity can lead to implant loosening, bacterial coloni-zation, and eventual failure. This thesis explores the development of bioactive glass coatings designed to address these challenges by enhancing osseointe-gration and providing antibacterial protection. Bioactive glasses based on the 45S5 Bioglass® composition were modified with varying concentrations of CuO, Nb₂O₅, ZrO₂, and Fe₃O₄ to enhance antibacterial activity and bioactivity. The incorporation of these oxides altered the glass net-work connectivity, affecting ion mobility, dissolution rates, and overall biological performance. In addition to structural and morphological characterization, the electrical properties were evaluated to assess the impact of oxide addition on charge storage capacity, which can influence the osseointegration process. Fol-lowing comprehensive structural, morphological, electrical, and biological evalu-ations, the optimal concentrations of each oxide were identified based on their cytocompatibility, bioactivity, antibacterial efficacy, and electrical properties. The optimized bioglass compositions were deposited onto Ti6Al4V metallic sub-strates using the CoBlast™ technique. This deposition method resulted in uni-form coatings with consistent microscale roughness and hydrophilic behavior, both favorable for promoting cell adhesion and proliferation. Mechanical testing confirmed the strong adhesion of the coatings to the substrates, ensuring dura-bility under physiological conditions. In vitro biological assays confirmed that all coatings supported cell adhesion and proliferation over time, while also exhibiting strong antibacterial activity, effectively reducing bacterial adhesion and biofilm formation. An enhancement in bioactivity was observed for the electrically charged coatings through the corona discharge compared to non-charged coat-ings. The findings of this thesis highlight the potential of oxide-modified bioactive glass coatings to improve implant longevity and biocompatibility, offering promising ap-plications in orthopaedic and dental fields. |
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