Detalhes bibliográficos
| Resumo: | Leveraging whole genome sequencing data of 1751 individuals from the UK and 2587 Qatari subjects, we suggest here an association of rare variants mapping to the sour taste-associated gene KCNJ2 with reduced low-density lipoprotein cholesterol (LDL-C, P = 2.10 × 10-12) and with a 22% decreased dietary trans-fat intake. This study identifies a novel candidate rare locus for LDL-C, adding insights into the genetic architecture of a complex trait implicated in cardiovascular disease. |
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| Autores principais: | Rossi, Niccolò |
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| Outros Autores: | Syed, Najeeb; Visconti, Alessia; Aliyev, Elbay; Berry, Sarah; Bourbon, Mafalda; Spector, Tim D.; Hysi, Pirro G.; Fakhro, Khalid A.; Falchi, Mario |
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| Assunto: | Familial Hypercholesterolaemia Doenças Cardio e Cérebro-vasculares LDL-cholesterol LDL-C Whole Genome Sequencing |
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| Ano: | 2024 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Instituto Nacional de Saúde Doutor Ricardo Jorge |
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| Idioma: | inglês |
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| Origem: | Repositório Científico do Instituto Nacional de Saúde |
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