Bibliographic Details
| Summary: | Immune checkpoint inhibitors (ICIs) are valuable therapeutic weapons against cancer that potentiate a T cell-mediated immune response. Nivolumab is an ICI that targets the PD-1 receptor. Rheumatic immune-related adverse events (irAEs), which are induced by ICIs, occur in 10% of cases. However, their pathogenesis remains unclear. Synovial biopsy has allowed for a better understanding of the underlying mechanisms of different arthropathies. Key message: Synovial biopsy has a role in understanding the aetiopathogenesis of immune checkpoint inhibitor-induced arthritis. |
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| Main Authors: | Costa, Roberto Pereira da |
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| Other Authors: | Pinho, Mafalda; Patrocínio, João; Torres, Sofia; Ferreira, Cristina; Fonseca, João Eurico; Khmelinskii, Nikita |
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| Subject: | Nivolumab-induced arthritis Synovial biopsy |
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| Year: | 2026 |
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| Country: | Portugal |
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| Document type: | article |
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| Access type: | open access |
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| Associated institution: | Instituto Politécnico de Lisboa |
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| Language: | English |
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| Origin: | Repositório Científico do Instituto Politécnico de Lisboa |
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