Publicação
Efficacy of botulinum toxin for poststroke lower limb: a systematic review and meta-analysis
| Resumo: | Objective: This review aims to conduct a systematic review and meta-analysis on the effectiveness ofbotulinum toxin in the treatment of spasticity and the improvement of lower limb function in adult strokesurvivors, based on randomized clinical trials.Data sources: Searches were conducted across multiple databases, including Medline, Scopus, CINAHL,SPORTDiscus, Psychology and Behavioral Sciences Collection, and Cochrane, from inception untilSeptember 2025.Review Method: This systematic review and meta-analysis was reported in accordance with thePreferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. The meta-ana-lysis was performed using Review Manager 5 software, with mean differences pooled using a random-effects model.Results: The analysis included 11 studies, with a total of 1740 adult participants. The results confirm thatbotulinum toxin is effective in reducing spasticity; however, the benefits on other outcomes, namely gaitand balance, were limited and inconsistent. Considerable heterogeneity was also observed in interventionprotocols, participant characteristics, dosing regimens, and the selection of target muscle groups.Conclusion: It is recommended that future studies prioritize the inclusion of subgroups and medium- andlong-term follow-up. Only in this way will it be possible to clarify the true efficacy of botulinum toxin indifferent patient profiles and to contribute to the optimization of lower limb rehabilitation strategies after stroke. |
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| Autores principais: | Fernandes, Carla Sílvia |
| Outros Autores: | Lima, Andreia Maria Novo; Moreira, Maria Teresa; Sousa, Salome Sobral; Ferreira, Salomé |
| Assunto: | Stroke Botulinum toxin Spasticity Lower limb Rehabilitation |
| Ano: | 2026 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Viana do Castelo |
| Idioma: | inglês |
| Origem: | Repositório Científico IPVC |
| Resumo: | Objective: This review aims to conduct a systematic review and meta-analysis on the effectiveness ofbotulinum toxin in the treatment of spasticity and the improvement of lower limb function in adult strokesurvivors, based on randomized clinical trials.Data sources: Searches were conducted across multiple databases, including Medline, Scopus, CINAHL,SPORTDiscus, Psychology and Behavioral Sciences Collection, and Cochrane, from inception untilSeptember 2025.Review Method: This systematic review and meta-analysis was reported in accordance with thePreferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. The meta-ana-lysis was performed using Review Manager 5 software, with mean differences pooled using a random-effects model.Results: The analysis included 11 studies, with a total of 1740 adult participants. The results confirm thatbotulinum toxin is effective in reducing spasticity; however, the benefits on other outcomes, namely gaitand balance, were limited and inconsistent. Considerable heterogeneity was also observed in interventionprotocols, participant characteristics, dosing regimens, and the selection of target muscle groups.Conclusion: It is recommended that future studies prioritize the inclusion of subgroups and medium- andlong-term follow-up. Only in this way will it be possible to clarify the true efficacy of botulinum toxin indifferent patient profiles and to contribute to the optimization of lower limb rehabilitation strategies after stroke. |
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