Detalhes bibliográficos
| Resumo: | In this work, the intramolecular C–H insertion of diazoacetamides catalyzed by dirhodium(II) complexes and using CO2 as solvent is disclosed. The expected lactams were obtained in yields over 97%. The asymmetric intramolecular C–H insertion was also achieved and the β-lactam 14 was obtained in >97% yield and 65% ee using the chiral dirhodium(II) catalyst Rh2(S-PTTL)4. Finally, the dirhodium(II) complex Rh2(OAc)4 was used in two consecutive cycles in which complete conversion to the lactam was observed. |
|---|
| Autores principais: | Zakrzewska, Malgorzata E. |
|---|
| Outros Autores: | Cal, Pedro M.S.D.; Candeias, Nuno R.; Lukasik, Rafal M.; Afonso, Carlos A.M.; Ponte, Manuel Nunes; Gois, Pedro M.P. |
|---|
| Assunto: | Diazoacetamides C–H insertion Dirhodium(II) Lactams scCO2 |
|---|
| Ano: | 2012 |
|---|
| País: | Portugal |
|---|
| Tipo de documento: | artigo |
|---|
| Tipo de acesso: | acesso aberto |
|---|
| Instituição associada: | Laboratório Nacional de Energia e Geologia, I.P. |
|---|
| Idioma: | inglês |
|---|
| Origem: | Repositório do LNEG |
|---|