Publicação
Synthesis and photorelease studies from model quinolone conjugates
| Resumo: | We present the synthesis and the photolytic release at longer wavelengths of phenylalanine, acting as a model amino acid, from conjugates bearing a methoxylated quinolone 2a,b. The photolytic study was carried out by irradiation at 300, 350 and 419 nm in a methanol/HEPES buffer solution (80:20). Monitoring of the photolysis of 2a,b and consequent release of N-benzyloxycarbonylphenylalanine was carried out by HPLC-UV detection and kinetic data was obtained. |
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| Autores principais: | Domingues, B. B. |
| Outros Autores: | Felgueiras, C. F. F.; Ferreira, M. A. L.; Pereira, A. S. R.; Gonçalves, M. Sameiro T.; Costa, Susana P. G.; Fonseca, Andrea Susana Cabral da |
| Assunto: | Photorelease Quinolone |
| Ano: | 2013 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | We present the synthesis and the photolytic release at longer wavelengths of phenylalanine, acting as a model amino acid, from conjugates bearing a methoxylated quinolone 2a,b. The photolytic study was carried out by irradiation at 300, 350 and 419 nm in a methanol/HEPES buffer solution (80:20). Monitoring of the photolysis of 2a,b and consequent release of N-benzyloxycarbonylphenylalanine was carried out by HPLC-UV detection and kinetic data was obtained. |
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