Detalhes bibliográficos
| Resumo: | Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntingtons disease (HD)-like symptoms in mice. Materials \& methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal lesions and motor deficit were induced in mice by 3-nitropropionic acid-intoxication. EGCG and EGCG/AA NPs were co-administered and behavioral motor assessments and striatal histology performed after 5 days. Results: EGCG/AA NPs were significantly more effective than free EGCG in reducing motor disturbances and depression-like behavior associated with 3-nitropropionic acid toxicity. EGCG/AA NPs treatment also mitigated neuroinflammation and prevented neuronal loss. Conclusion: NP encapsulation enhances therapeutic robustness of EGCG in this model of HD symptomatology. Together with our previous findings, this highlights the potential of EGCG/AA NPs in the symptomatic treatment of neurodegenerative diseases. |
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| Autores principais: | Cano, Amanda |
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| Outros Autores: | Ettcheto, Miren; Espina, Marta; Auladell, Carmen; Folch, Jaume; Kühne, Britta A; Barenys, Marta; Sánchez-López, Elena; Souto, Eliana B.; García, Maria Luisa; Turowski, Patric; Camins, Antonio |
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| Assunto: | 3-nitropropionic acide pigallocatechin-3-gallate Huntingtons disease neurodegenerative diseases PLGA-PEG polymeric nanoparticles 3-nitropropionic acid epigallocatechin-3-gallate Ciências Naturais::Ciências Biológicas |
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| Ano: | 2020 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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