Detalhes bibliográficos
| Resumo: | Comparative genomic hybridization (CGH) has been the technique of choice over the last 10 years for mapping DNA copy number changes in human tumors. Here we review the literature to demonstrate how CGH has contributed to the comprehension of molecular aspects of breast tumorigenesis. At least two distinct molecular pathways of breast cancer have been characterized that show a strong correlation with histological grade. It seems that grade I invasive ductal carcinomas (IDCs) arise from well-differentiated ductal carcinoma in situ (DCIS), whereas grade III IDCs come from poorly differentiated DCIS. In addition, dedifferentiation from a low- to a high-grade breast cancer has proven an unlikely phenomenon. CGH has been instrumental in dissecting distinct molecular pathways toward breast malignancy and in establishing a direct relationship between genotype and clinical pathological features. |
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| Autores principais: | Reis-Filho, Jorge S. |
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| Outros Autores: | Simpson, Peter T.; Gale, Theodora; Lakhani, Sunil R. |
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| Assunto: | Breast Breast Neoplasms Carcinoma in Situ Carcinoma, Ductal, Breast Carcinoma, Intraductal, Noninfiltrating Chromosome Mapping DNA, Neoplasm Genotype Humans Hyperplasia Phenotype Nucleic Acid Hybridization Breast cancer Comparative genomic hybridization DNA copy number changes Loss of heterozygosity |
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| Ano: | 2005 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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