Publicação
Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma
| Resumo: | Monocarboxylate transporters (MCTs) have been considered promising targets for cancer therapy, since they facilitate lactate efflux in glycolytic tumours. However, their role in solid tumours is still poorly understood. Thus, the present work aimed to contribute to understanding the involvement of MCT1 and MCT4 in breast cancer progression as well as MCT regulation by CD147. |
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| Autores principais: | Pinheiro, Céline |
| Outros Autores: | Albergaria, André; Paredes, Joana; Sousa, Bárbara; Dufloth, Rozany; Vieira, Daniella; Schmitt, Fernando; Baltazar, Fátima |
| Assunto: | Adult Aged Aged, 80 and over Basigin Breast neoplasms Carcinoma Disease-Free Survival Female Humans Immunohistochemistry Kaplan-Meier Estimate Middle aged Monocarboxylic acid transporters Muscle proteins Prognosis Symporters Up-Regulation breast carcinoma CD147 monocarboxylate transporter |
| Ano: | 2010 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Monocarboxylate transporters (MCTs) have been considered promising targets for cancer therapy, since they facilitate lactate efflux in glycolytic tumours. However, their role in solid tumours is still poorly understood. Thus, the present work aimed to contribute to understanding the involvement of MCT1 and MCT4 in breast cancer progression as well as MCT regulation by CD147. |
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