Detalhes bibliográficos
| Resumo: | Digestive system cancers account for nearly half of all cancers around the world and have a high mortality rate. Cell culture and animal models represent cornerstones of digestive cancer research. However, their ability to en- able cancer precision medicine is limited. Cell culture models cannot retain the genetic and phenotypic heteroge- neity of tumors and lack tumor microenvironment (TME). Patient-derived xenograft mouse models are not suitable for immune-oncology research. While humanized mouse models are time- and cost-consuming. Suitable preclinical models, which can facilitate the understanding of mechanisms of tumor progression and develop new therapeutic strategies, are in high demand. This review article summarizes the recent progress on the establish- ment of TME by using tumor organoid models and microfluidic systems. The main challenges regarding the translation of organoid models from bench to bedside are discussed. The integration of organoids and a microflu- idic platform is the emerging trend in drug screening and precision medicine. A future prospective on this field is also provided. |
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| Autores principais: | Song, Sheng-Lei |
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| Outros Autores: | Li, Bo; Carvalho, M. R.; Wang, H. - J.; Mao, De-Li; Wei, Ji-Tao; Chen, W.; Weng, Zhi-Hui; Chen, Yang-Chao; Deng, Chu-Xia; Reis, R. L.; Oliveira, Joaquim M.; He, Yu-Long; Yan, L. P.; Zhang, Chang-Hua |
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| Assunto: | Digestive system in vitro models tumour Digestive system cancer Tumor microenvironment In vitro 3D models Organoids cancer-on-a-chip |
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| Ano: | 2022 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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