Publicação
The aggressiveness of urothelial carcinoma depends to a large extent on lymphovascular invasion--the prognostic contribution of related molecular markers
| Resumo: | Bladder cancer is the second most common malignancy of the urogenital region. The majority of bladder cancer deaths occur as a consequence of metastatic disease. Blood vessel density (BVD), a surrogate marker for angiogenesis, has been shown to be predictive of progression and poor prognosis, as well as lymphatic vessel density (LVD). The aim of this study was to evaluate, in human urothelial bladder cancer (UBC), the clinical and prognostic significance of angiogenesis, lymphangiogenesis and lymphovascular invasion, assessed with the use of specific immunohistochemical markers. |
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| Autores principais: | Afonso, Julieta Alexandra Pereira |
| Outros Autores: | Santos, Lúcio Lara; Amaro, Teresina; Lobo, Francisco; Longatto, Adhemar |
| Assunto: | Adult Aged Aged, 80 and over Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Biomarkers, Tumor Carcinoma, Transitional cell Female Humans Immunohistochemistry Kaplan-Meier estimate Lymphangiogenesis Male Middle aged Neoplasm staging Neovascularization, Pathologic Platelet endothelial cell adhesion molecule-1 Prognosis Urinary bladder neoplasms blood vessel density CD-31 lymphatic vessel density urothelial carcinoma VEGFR-C VEGFR-3 |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Bladder cancer is the second most common malignancy of the urogenital region. The majority of bladder cancer deaths occur as a consequence of metastatic disease. Blood vessel density (BVD), a surrogate marker for angiogenesis, has been shown to be predictive of progression and poor prognosis, as well as lymphatic vessel density (LVD). The aim of this study was to evaluate, in human urothelial bladder cancer (UBC), the clinical and prognostic significance of angiogenesis, lymphangiogenesis and lymphovascular invasion, assessed with the use of specific immunohistochemical markers. |
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