Detalhes bibliográficos
| Resumo: | The development of injectable bone substitutes (IBS) have obtained great importance in the bone regeneration field, as a strategy to reach hardly accessible defects using minimally invasive techniques and able to fit to irregular topographies. In this scenario, the association of injectable hydrogels and bone graft granules is emerging as a well-established trend. Particularly, in situ forming hydrogels have arisen as a new IBS generation. An in situ forming and injectable dextrin-based hydrogel (HG) was developed, aiming to act as a carrier of granular bone substitutes and bioactive agents. In this work, the HG was associated to a granular bone substitute (Bonelike®) and implanted in goat critical-sized calvarial defects (14mm) for 3, 6 and 12weeks. The results showed that HG improved the handling properties of the Bonelike® granules and did not affect its osteoconductive features, neither impairing the bone regeneration process. Human multipotent mesenchymal stromal cells from the umbilical cord, extracellular matrix hydrolysates and the pro-angiogenic peptide LLKKK18 were also combined with the IBS. These bioactive agents did not enhance the new bone formation significantly under the conditions tested, according to micro-computed tomography and histological analysis. |
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| Autores principais: | Pereira, Isabel Sofia Melo |
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| Outros Autores: | Pereira, José Eduardo; Maltez, Luís; Rodrigues, Alexandra; Rodrigues, Catarina; Oliveira, Manuela; Silva, Dina M.; Caseiro, Ana Rita; Prada, Justina; Maurício, Ana Colette; Santos, José Domingos; Gama, F. M. |
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| Assunto: | Polysaccharide Injectable hydrogel Granular ceramics Bonelike® Bone regeneration Calvarial defect Bonelike (R) |
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| Ano: | 2021 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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