Publicação
Synthetic biology approaches for biosurfactants production by lactic acid bacteria
| Resumo: | Biosurfactants are surface active molecules produced by microbes and have received increased attention, mainly due to their extraordinary properties and extensive potential applications. Lactic acid bacteria (LAB) such as Lactobacillus, Lactococcus, and Streptococcus are known to produce different types of biosurfactants with antiviral, antibacterial, and antifungal activities, besides presenting antiadhesive properties against numerous pathogenic strains. These biological activities combined with their probiotic nature make LAB very promising candidates for several biomedical applications. Therefore, we believe that unraveling the biosynthetic pathways of these molecules could allow developing more sustainable bioprocesses and designing novel and/or improved molecules. This chapter explores the use of emergent molecular, synthetic, and systems biology tools to discover LAB biosurfactants production pathways and to expand LAB as biosurfactant cell factories toward innovative and sustainable industrial applications. |
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| Autores principais: | Rodrigues, Joana Lúcia Lima Correia |
| Outros Autores: | Rodrigues, L. R. |
| Assunto: | Biosurfactants Lactic acid bacteria Synthetic biology Metabolic engineering Biosynthetic pathways Surfactin pathway |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Biosurfactants are surface active molecules produced by microbes and have received increased attention, mainly due to their extraordinary properties and extensive potential applications. Lactic acid bacteria (LAB) such as Lactobacillus, Lactococcus, and Streptococcus are known to produce different types of biosurfactants with antiviral, antibacterial, and antifungal activities, besides presenting antiadhesive properties against numerous pathogenic strains. These biological activities combined with their probiotic nature make LAB very promising candidates for several biomedical applications. Therefore, we believe that unraveling the biosynthetic pathways of these molecules could allow developing more sustainable bioprocesses and designing novel and/or improved molecules. This chapter explores the use of emergent molecular, synthetic, and systems biology tools to discover LAB biosurfactants production pathways and to expand LAB as biosurfactant cell factories toward innovative and sustainable industrial applications. |
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