Detalhes bibliográficos
| Resumo: | Aim: In this work, we established a simple, controlled, and reproducible method to synthesize gallium-coated polydopamine (PDA) nanoparticles. Methods: Polydopamine was synthetized in the alkali medium with posterior gallium shell formation due to ion chelation on the nanoparticle surface. Results: The obtained results with EDS spectra confirmed the incorporation of gallium on PDA surface. The cytotoxicity of Ga-coated PDA nanoparticles was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells (hASCs). Further cell analysis also demonstrated the benefit of Ga-coated PDA, which increased the cell proliferation rate compared to non-coated PDA. Conclusion: This study indicated that gallium could work as an appropriate shell for PDA particles, inducing cell proliferation at the analyzed concentrations. |
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| Autores principais: | Teixeira, Jean Valdir Uchôa |
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| Outros Autores: | Maia, F. Raquel; Carvalho, Mariana R.; Reis, R. L.; Oliveira, J. M.; Lisboa-Filho, Paulo Noronha; Claro, Ana Paula Rosifni Alves |
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| Assunto: | Core/shell Cytotoxicity Gallium incorporation Nanoparticle synthesis |
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| Ano: | 2021 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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