Publicação
Schizophrenia, comorbidities and readmission esquizofrenia, comorbilidades e readmissão
| Resumo: | Schizophrenia is a psychiatric disease with idiopathic aetiology, being the theory of the dopaminergic hyperfunction the most accepted one to explain its physiopathology. Recently, other theories have emerged: the glutamatergic and neurodevelopment theory. This disease has also been associated to several medical comorbidities (obesity, blood pressure changes and thyroid diseases) that contribute to the lack of therapeutic adhesion and posterior readmissions. This study was performed by assessing 107 medical records admitted at Casa de Saúde do Bom Jesus (CSBJ), in Braga, throughout a period of five years (2007-2012). Patients were all women with ages between 18 and 64 years old. Statistical analysis was performed using SPSS (version 22); the significance was defined as p <0.05. Time of hospital stay, medical comorbidities, difference of admission days and social-demographic variables were analysed based on the descriptive statistics. One way ANOVA and a multinomial regression model were performed to assess readmission and determine the readmission predictors up to the third admission. Furthermore the test 2 was performed to assess the degree of association between readmission, medical comorbidities and the different types of antipsychotic treatments. Finally, a binary logistical regression model was used to assess the degree of association between the independent variables (different comorbidities, type of antipsychotic treatments and the different types of treatment) with the dependent variable (number of admissions). Results show that most patients were young adult women with ages between 20 and 29 years old, single (54%), with a low level of school education (41.58%), residing in urban areas (55.95%), with unskilled employment and a high functional level, few readmissions (3) and a longer interval between readmissions (3 years), who showed several medical comorbidities (obesity, thyroid disease and blood pressure changes), being obesity.probabily related with genetic factors and aggravated by atypical antipsychotics. That treatment and thyroid dysfunction are supposed to contribute to the reduction of the risk of readmission. On the other hand, treatment with combined antipsychotics reduced the risk of patients developing thyroid disease. Regarding blood pressure changes, classic antipsychotics showed a lower risk of causing hypotension when compared to atypical ones. |
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| Autores principais: | Sulemane, Sámia Issufo |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Schizophrenia is a psychiatric disease with idiopathic aetiology, being the theory of the dopaminergic hyperfunction the most accepted one to explain its physiopathology. Recently, other theories have emerged: the glutamatergic and neurodevelopment theory. This disease has also been associated to several medical comorbidities (obesity, blood pressure changes and thyroid diseases) that contribute to the lack of therapeutic adhesion and posterior readmissions. This study was performed by assessing 107 medical records admitted at Casa de Saúde do Bom Jesus (CSBJ), in Braga, throughout a period of five years (2007-2012). Patients were all women with ages between 18 and 64 years old. Statistical analysis was performed using SPSS (version 22); the significance was defined as p <0.05. Time of hospital stay, medical comorbidities, difference of admission days and social-demographic variables were analysed based on the descriptive statistics. One way ANOVA and a multinomial regression model were performed to assess readmission and determine the readmission predictors up to the third admission. Furthermore the test 2 was performed to assess the degree of association between readmission, medical comorbidities and the different types of antipsychotic treatments. Finally, a binary logistical regression model was used to assess the degree of association between the independent variables (different comorbidities, type of antipsychotic treatments and the different types of treatment) with the dependent variable (number of admissions). Results show that most patients were young adult women with ages between 20 and 29 years old, single (54%), with a low level of school education (41.58%), residing in urban areas (55.95%), with unskilled employment and a high functional level, few readmissions (3) and a longer interval between readmissions (3 years), who showed several medical comorbidities (obesity, thyroid disease and blood pressure changes), being obesity.probabily related with genetic factors and aggravated by atypical antipsychotics. That treatment and thyroid dysfunction are supposed to contribute to the reduction of the risk of readmission. On the other hand, treatment with combined antipsychotics reduced the risk of patients developing thyroid disease. Regarding blood pressure changes, classic antipsychotics showed a lower risk of causing hypotension when compared to atypical ones. |
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