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Electroactive poly(vinylidene fluoride) electrospun fiber mats coated with polyaniline and polypyrrole for tissue regeneration applications

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Detalhes bibliográficos
Resumo:Electrospun membranes with an active response are playing an increasing role in tissue regeneration by improving the ability of the materials to mimic the cellular microenvironment during cell culture. In this context, this work reports on the development of poly(vinylidene fluoride) (PVDF) electrospun fibers coated with polyaniline (PANI) and with polypyrrole (PPy). Both PANI and PPy successfully coated the fibers, with the surface electrical conductivity of the coatings reaching values of =1.19S.m1 for PVDF-PPy and =3.84×103S.m1 for PVDF-PANI. Furthermore, the PVDF samples became hydrophilic upon their coating with either PANI or PPy, the fiber mats adsorbing the water drop after a few seconds. The coated samples remain biocompatible, resulting in a slight improvement in the metabolic activity of L929 fibroblasts.
Autores principais:Hermenegildo, Bruno Filipe Costa
Outros Autores:Ribeiro, Clarisse Marta Oliveira; Perinka, N.; Martins, Pedro Libânio Abreu; Trchová, M.; Hajná, M.; Stejskal, J.; Lanceros-Méndez, S.
Assunto:Tissue engineering Electrospun membranes Poly(vinylidene fluoride) Polyaniline Polypyrrole
Ano:2022
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:Electrospun membranes with an active response are playing an increasing role in tissue regeneration by improving the ability of the materials to mimic the cellular microenvironment during cell culture. In this context, this work reports on the development of poly(vinylidene fluoride) (PVDF) electrospun fibers coated with polyaniline (PANI) and with polypyrrole (PPy). Both PANI and PPy successfully coated the fibers, with the surface electrical conductivity of the coatings reaching values of =1.19S.m1 for PVDF-PPy and =3.84×103S.m1 for PVDF-PANI. Furthermore, the PVDF samples became hydrophilic upon their coating with either PANI or PPy, the fiber mats adsorbing the water drop after a few seconds. The coated samples remain biocompatible, resulting in a slight improvement in the metabolic activity of L929 fibroblasts.