Detalhes bibliográficos
| Resumo: | To improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 Vâ 30 min, using an ethylene glycol solution containing 0.3% NH4F and 3% H2O, at a speed of 100 rpm). A nanotube layer composed mainly of α-Fe2O3 with diameters between 60 and 70 nm was obtained. The effect of the Fe-oxide nanotube layer on cell viability and morphology was evaluated by in vitro studies using a human osteosarcoma cell line (SaOs-2 cells). The results showed that the presence of this layer did not harm the viability or morphology of the cells. Furthermore, cells cultured on anodized surfaces showed higher metabolic activity than those on non-anodized surfaces. This research suggests that growing a layer of Fe oxide nanotubes on pure Fe is a promising method for functionalizing and improving the cytocompatibility of iron substrates. This opens up new opportunities for biomedical applications, including the development of cardiovascular stents or osteosynthesis implants. |
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| Autores principais: | Rangel, Rita de Cássia Reis |
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| Outros Autores: | Rangel, André Luiz Reis; Silva, Kerolene Barboza da; Escada, Ana Lúcia do Amaral; Chaves, Javier Andres Munoz; Maia, F. Raquel; Pina, Sandra Cristina Almeida; Reis, R. L.; Oliveira, Joaquim M.; Alves, Ana Paula Rosifini |
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| Assunto: | Biodegradable biomaterials Biodegradable metal Surface modification |
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| Ano: | 2024 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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