Publicação
Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies
| Resumo: | To improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 Vâ 30 min, using an ethylene glycol solution containing 0.3% NH4F and 3% H2O, at a speed of 100 rpm). A nanotube layer composed mainly of α-Fe2O3 with diameters between 60 and 70 nm was obtained. The effect of the Fe-oxide nanotube layer on cell viability and morphology was evaluated by in vitro studies using a human osteosarcoma cell line (SaOs-2 cells). The results showed that the presence of this layer did not harm the viability or morphology of the cells. Furthermore, cells cultured on anodized surfaces showed higher metabolic activity than those on non-anodized surfaces. This research suggests that growing a layer of Fe oxide nanotubes on pure Fe is a promising method for functionalizing and improving the cytocompatibility of iron substrates. This opens up new opportunities for biomedical applications, including the development of cardiovascular stents or osteosynthesis implants. |
|---|---|
| Autores principais: | Rangel, Rita de Cássia Reis |
| Outros Autores: | Rangel, André Luiz Reis; Silva, Kerolene Barboza da; Escada, Ana Lúcia do Amaral; Chaves, Javier Andres Munoz; Maia, F. Raquel; Pina, Sandra Cristina Almeida; Reis, R. L.; Oliveira, Joaquim M.; Alves, Ana Paula Rosifini |
| Assunto: | Biodegradable biomaterials Biodegradable metal Surface modification |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1866270671575711744 |
|---|---|
| author | Rangel, Rita de Cássia Reis |
| author2 | Rangel, André Luiz Reis Silva, Kerolene Barboza da Escada, Ana Lúcia do Amaral Chaves, Javier Andres Munoz Maia, F. Raquel Pina, Sandra Cristina Almeida Reis, R. L. Oliveira, Joaquim M. Alves, Ana Paula Rosifini |
| author2_role | author author author author author author author author author |
| author_facet | Rangel, Rita de Cássia Reis Rangel, André Luiz Reis Silva, Kerolene Barboza da Escada, Ana Lúcia do Amaral Chaves, Javier Andres Munoz Maia, F. Raquel Pina, Sandra Cristina Almeida Reis, R. L. Oliveira, Joaquim M. Alves, Ana Paula Rosifini |
| author_role | author |
| contributor_name_str_mv | Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Rangel, Rita de Cássia Reis\"},{\"Person.name\":\"Rangel, André Luiz Reis\"},{\"Person.name\":\"Silva, Kerolene Barboza da\"},{\"Person.name\":\"Escada, Ana Lúcia do Amaral\"},{\"Person.name\":\"Chaves, Javier Andres Munoz\"},{\"Person.name\":\"Maia, F. Raquel\"},{\"Person.name\":\"Pina, Sandra Cristina Almeida\"},{\"Person.name\":\"Reis, R. L.\"},{\"Person.name\":\"Oliveira, Joaquim M.\"},{\"Person.name\":\"Alves, Ana Paula Rosifini\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Rangel, Rita de Cássia Reis Rangel, André Luiz Reis Silva, Kerolene Barboza da Escada, Ana Lúcia do Amaral Chaves, Javier Andres Munoz Maia, F. Raquel Pina, Sandra Cristina Almeida Reis, R. L. Oliveira, Joaquim M. Alves, Ana Paula Rosifini |
| datacite.date.Accepted.fl_str_mv | 2024-07-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-07-26T15:19:06Z |
| datacite.date.embargoed.fl_str_mv | 2024-07-26T15:19:06Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Biodegradable biomaterials Biodegradable metal Surface modification |
| datacite.titles.title.fl_str_mv | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies |
| dc.contributor.none.fl_str_mv | Universidade do Minho |
| dc.creator.none.fl_str_mv | Rangel, Rita de Cássia Reis Rangel, André Luiz Reis Silva, Kerolene Barboza da Escada, Ana Lúcia do Amaral Chaves, Javier Andres Munoz Maia, F. Raquel Pina, Sandra Cristina Almeida Reis, R. L. Oliveira, Joaquim M. Alves, Ana Paula Rosifini |
| dc.date.Accepted.fl_str_mv | 2024-07-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-07-26T15:19:06Z |
| dc.date.embargoed.fl_str_mv | 2024-07-26T15:19:06Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/92623 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Biodegradable biomaterials Biodegradable metal Surface modification |
| dc.title.fl_str_mv | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | To improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 Vâ 30 min, using an ethylene glycol solution containing 0.3% NH4F and 3% H2O, at a speed of 100 rpm). A nanotube layer composed mainly of α-Fe2O3 with diameters between 60 and 70 nm was obtained. The effect of the Fe-oxide nanotube layer on cell viability and morphology was evaluated by in vitro studies using a human osteosarcoma cell line (SaOs-2 cells). The results showed that the presence of this layer did not harm the viability or morphology of the cells. Furthermore, cells cultured on anodized surfaces showed higher metabolic activity than those on non-anodized surfaces. This research suggests that growing a layer of Fe oxide nanotubes on pure Fe is a promising method for functionalizing and improving the cytocompatibility of iron substrates. This opens up new opportunities for biomedical applications, including the development of cardiovascular stents or osteosynthesis implants. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://prod-dspace.uminho.pt/bitstreams/4c6be76a-a9cd-45d1-9cb0-81f937797978/download |
| id | rum_4e090e49a282cd5d7330010758405591 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/92623 |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/92623 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Rangel, Rita de Cássia Reis Rangel, André Luiz Reis Silva, Kerolene Barboza da Escada, Ana Lúcia do Amaral Chaves, Javier Andres Munoz Maia, F. Raquel Pina, Sandra Cristina Almeida Reis, R. L. Oliveira, Joaquim M. Alves, Ana Paula Rosifini |
| publishDate | 2024 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMDPIporTo improve the biocompatibility and bioactivity of biodegradable iron-based materials, nanostructured surfaces formed by metal oxides offer a promising strategy for surface functionalization. To explore this potential, iron oxide nanotubes were synthesized on pure iron (Fe) using an anodic oxidation process (50 Vâ 30 min, using an ethylene glycol solution containing 0.3% NH4F and 3% H2O, at a speed of 100 rpm). A nanotube layer composed mainly of α-Fe2O3 with diameters between 60 and 70 nm was obtained. The effect of the Fe-oxide nanotube layer on cell viability and morphology was evaluated by in vitro studies using a human osteosarcoma cell line (SaOs-2 cells). The results showed that the presence of this layer did not harm the viability or morphology of the cells. Furthermore, cells cultured on anodized surfaces showed higher metabolic activity than those on non-anodized surfaces. This research suggests that growing a layer of Fe oxide nanotubes on pure Fe is a promising method for functionalizing and improving the cytocompatibility of iron substrates. This opens up new opportunities for biomedical applications, including the development of cardiovascular stents or osteosynthesis implants.application/pdfporCharacterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studiesRangel, Rita de Cássia ReisRangel, André Luiz ReisSilva, Kerolene Barboza daEscada, Ana Lúcia do AmaralChaves, Javier Andres MunozMaia, F. RaquelPina, Sandra Cristina AlmeidaReis, R. L.Oliveira, Joaquim M.Alves, Ana Paula RosifiniHostingInstitutionOrganizationalUniversidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptISSNIsPartOf1996-1944DOIIsPartOf10.3390/ma171536272024-07-26T15:19:06Z2024-072024-072024-07-25T16:30:05Z2024-07-01T00:00:00ZHandlehttps://hdl.handle.net/1822/92623http://purl.org/coar/access_right/c_abf2open accessBiodegradable biomaterialsBiodegradable metalSurface modification6122338 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://prod-dspace.uminho.pt/bitstreams/4c6be76a-a9cd-45d1-9cb0-81f937797978/download |
| spellingShingle | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies Rangel, Rita de Cássia Reis Biodegradable biomaterials Biodegradable metal Surface modification |
| status | SINGLETON |
| subject.fl_str_mv | Biodegradable biomaterials Biodegradable metal Surface modification |
| title | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies |
| title_full | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies |
| title_fullStr | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies |
| title_full_unstemmed | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies |
| title_short | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies |
| title_sort | Characterization of iron oxide nanotubes obtained by anodic oxidation for biomedical applications—In vitro studies |
| topic | Biodegradable biomaterials Biodegradable metal Surface modification |
| topic_facet | Biodegradable biomaterials Biodegradable metal Surface modification |
| url | https://hdl.handle.net/1822/92623 |
| visible | 1 |