Publicação
Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines
| Resumo: | The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumour cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma)) were evaluated, and discussed in terms of structure–activity relationship. |
|---|---|
| Autores principais: | Francisco, Carla S. |
| Outros Autores: | Rodrigues, L. R.; Cerqueira, N. M. F. S. A.; Campos, Ana M. F. Oliveira; Rodrigues, Lígia M. |
| Assunto: | Benzofurocoumarins; Benzopsoralen analogues Antitumour activity Docking Computational studies Antitumor activity |
| Ano: | 2012 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumour cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma)) were evaluated, and discussed in terms of structure–activity relationship. |
|---|