Detalhes bibliográficos
| Resumo: | Eukaryotic cells internalize or recycle their plasma membrane proteins by endocytosis in response to physiological or stress signals imposed by a changing environment. Defects in membrane cargo trafficking lead to protein mislocalization and activation of turnover pathways, which can result into cellular stress and is often related to human diseases. The α-arrestins connect signalling pathways triggered by external stimuli to the endocytosis of specific plasma membrane transporters or receptors. The Saccharomyces cerevisiae lactate transporter Jen1p has been used as a model membrane cargo protein for elucidating aspects of the mechanisms that control the endocytic turnover of specific transporters in response to the presence of glucose. Here, we discover a novel pathway of Jen1p endocytosis and provide further insights on how particular α-arrestins mediate the ubiquitylation of transporters under distinct physiological conditions (presence of cycloheximide or prolonged growth in lactate). |
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| Autores principais: | Talaia, Gabriel |
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| Outros Autores: | Gournas, Christos; Saliba, Elie; Antunes, Cláudia Barata; Casal, Margarida; André, Bruno; Diallinas, George; Paiva, Sandra |
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| Assunto: | Ciências Naturais::Ciências Biológicas |
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| Ano: | 2017 |
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| País: | Portugal |
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| Tipo de documento: | póster em conferência |
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| Tipo de acesso: | acesso restrito |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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