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The neurobiological hypothesis of neurotrophins in the pathophysiology of schizophrenia: A meta-analysis

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Detalhes bibliográficos
Resumo:Schizophrenia is associated with patterns of aberrant neurobiological circuitry. The disease complexity is mirrored by multiple biological interactions known to contribute to the disease pathology. One potential contributor is the family of neurotrophins which are proteins involved in multiple functional processes in the nervous system, with crucial roles in neurodevelopment, synaptogenesis and neuroplasticity. With these roles in mind, abnormal neurotrophin profiles have been hypothesized to contribute to the pathology of schizophrenia.
Autores principais:Rodrigues-Amorim, Daniela
Outros Autores:Rivera-Baltanás, Tania; Peixoto, João Miguel Seiça Bessa; Sousa, Nuno; Vallejo-Curto, María de Carmen; Rodríguez-Jamardo, Cynthia; de Las Heras, María Elena; Díaz, Roberto; Agís-Balboa, Roberto Carlos; Olivares, J. M.; Spuch, Carlos
Assunto:Ciências Médicas::Medicina Básica
Ano:2018
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:Schizophrenia is associated with patterns of aberrant neurobiological circuitry. The disease complexity is mirrored by multiple biological interactions known to contribute to the disease pathology. One potential contributor is the family of neurotrophins which are proteins involved in multiple functional processes in the nervous system, with crucial roles in neurodevelopment, synaptogenesis and neuroplasticity. With these roles in mind, abnormal neurotrophin profiles have been hypothesized to contribute to the pathology of schizophrenia.