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Acetyl Cholinesterase Inhibitors and Cell-Derived Peripheral Inflammatory Cytokines in Early Stages of Alzheimer's Disease

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Bibliographic Details
Summary:Clinical and preclinical studies firmly support the involvement of the inflammation in the pathogenesis of Alzheimer's disease (AD). Despite acetylcholinesterase inhibitors (AChEI) being widely used in AD patients, there is no conclusive evidence about their impact on the inflammatory response.
Main Authors:Kokras, Nikolaos
Other Authors:Stamouli, Evangelia; Sotiropoulos, I.; Katirtzoglou, Everina A.; Siarkos, Kostas T.; Dalagiorgou, Georgia; Alexandraki, Krystallenia I.; Coulocheri, Stavroula; Piperi, Christina; Politis, Antonios M.
Subject:Aged Alzheimer Disease Cholinesterase Inhibitors Cytokines Donepezil Female Follow-Up Studies Humans Indans Inflammation Male Middle Aged Piperidines Alzheimer's disease anticholinesterase inhibitors
Year:2018
Country:Portugal
Document type:article
Access type:open access
Associated institution:Universidade do Minho
Language:English
Origin:RepositóriUM - Universidade do Minho
Description
Summary:Clinical and preclinical studies firmly support the involvement of the inflammation in the pathogenesis of Alzheimer's disease (AD). Despite acetylcholinesterase inhibitors (AChEI) being widely used in AD patients, there is no conclusive evidence about their impact on the inflammatory response.