Publicação

Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

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Detalhes bibliográficos
Resumo:Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.
Autores principais:Ruesen, Carolien
Outros Autores:Chaidir, Lidya; van Laarhoven, Arjan; Dian, Sofiati; Ganiem, Ahmad Rizal; Guimarães, Hanna Nebenzahl; Huynen, Martijn A.; Alisjahbana, Bachti; Dutilh, Bas E.; van Crevel, Reinout
Assunto:Computational Biology Genomics Humans Indonesia Mycobacterium tuberculosis Phenotype Phylogeny Polymorphism, Single Nucleotide Tuberculosis, Meningeal Tuberculosis, Pulmonary Genes, Bacterial Genetic Variation Genome, Bacterial Pulmonary tuberculosis Tuberculous meningitis Whole genome sequencing Homoplasy
Ano:2018
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.