Publicação
Tendon stem cell niche
| Resumo: | Tendon stem cells constitute a heterogeneous population of stem and progenitor cells that is involved in tendon formation and healing. The basic understanding of the interactions between tendon cells and their surroundings can enable the development of improved regenerative therapies. In this chapter, the main characteristics of their microenvironment â niche â are reviewed. In particular, the importance of signaling molecules and extracellular matrix (ECM) are highlighted, focusing on their potential role in tendon regeneration. |
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| Autores principais: | Almeida, Raquel Carvalho Ferreira Costa |
| Outros Autores: | Gonçalves, Ana Isabel Silva; Gershovich, Pavel; Rodrigues, Márcia T.; Reis, R. L.; Gomes, Manuela E. |
| Assunto: | Cell therapy Extracellular matrix Niche Regenerative medicine Tendon healing/repair Tendon stem/progenitor cells Tenogenesis |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Tendon stem cells constitute a heterogeneous population of stem and progenitor cells that is involved in tendon formation and healing. The basic understanding of the interactions between tendon cells and their surroundings can enable the development of improved regenerative therapies. In this chapter, the main characteristics of their microenvironment â niche â are reviewed. In particular, the importance of signaling molecules and extracellular matrix (ECM) are highlighted, focusing on their potential role in tendon regeneration. |
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