Publicação
Development of a biomimetic finite element model of the intervertebral disc diseases and regeneration
| Resumo: | Degenerative Disc Disease is one of the largest health problems faced worldwide, based on lost working time and associated costs. This is the driving force for the development of a biomimetic Finite Element (FE) model of the Intervertebral Disc (IVD), which is a multiphasic and highly inhomogeneous structure. A great amount of experimental and numerical works have studied the IVD and proven that it presents osmo-poro-hyper-visco-elastic behavior, with high influence of the anisotropic behavior of collagen fibers. Poroelastic models of the IVD are mostly implemented in commercial FE-packages, which means that the accessibility to the source algorithm is often circumscribed. In order to approach to the biomechanical behavior of the IVD in the Human spine with higher flexibility and accuracy, an innovative poroelastic formulation implemented on a home-developed open-source FE solver is addressed and validated throughout this work. Numerical simulations were mostly devoted to the analysis of the non-degenerated Human IVD time-dependent behavior, using a geometrically accurate FE model of a full motion segment (MS), constructed with quadratic 27 nodes hexaedral elements. The results of the tests performed for creep assessment were inside the scope of the experimental and numerical literature data, with remarkable improvements of the numerical accuracy when compared with some previously published results obtained with the commercial FE-package ABAQUS®. Previously unpublished experimental data from the research partners at VUmc (Amsterdam, The Netherlands) were also analyzed and compared with the MS FE model, which proved to reproduce satisfactorily to the physiological and non-physiological conditions of those experimental tests. The IVD biomechanical behavioral is complex and dependent on multiple factors. The numerical simulations with the present MS FE model, using the home-developed open-source FE solver, demonstrated potential to biomimitize the IVD and thus contribute to the advance of the knowledge on its biomechanics. |
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| Autores principais: | Castro, André |
| Ano: | 2013 |
| País: | Portugal |
| Tipo de documento: | tese de doutoramento |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Degenerative Disc Disease is one of the largest health problems faced worldwide, based on lost working time and associated costs. This is the driving force for the development of a biomimetic Finite Element (FE) model of the Intervertebral Disc (IVD), which is a multiphasic and highly inhomogeneous structure. A great amount of experimental and numerical works have studied the IVD and proven that it presents osmo-poro-hyper-visco-elastic behavior, with high influence of the anisotropic behavior of collagen fibers. Poroelastic models of the IVD are mostly implemented in commercial FE-packages, which means that the accessibility to the source algorithm is often circumscribed. In order to approach to the biomechanical behavior of the IVD in the Human spine with higher flexibility and accuracy, an innovative poroelastic formulation implemented on a home-developed open-source FE solver is addressed and validated throughout this work. Numerical simulations were mostly devoted to the analysis of the non-degenerated Human IVD time-dependent behavior, using a geometrically accurate FE model of a full motion segment (MS), constructed with quadratic 27 nodes hexaedral elements. The results of the tests performed for creep assessment were inside the scope of the experimental and numerical literature data, with remarkable improvements of the numerical accuracy when compared with some previously published results obtained with the commercial FE-package ABAQUS®. Previously unpublished experimental data from the research partners at VUmc (Amsterdam, The Netherlands) were also analyzed and compared with the MS FE model, which proved to reproduce satisfactorily to the physiological and non-physiological conditions of those experimental tests. The IVD biomechanical behavioral is complex and dependent on multiple factors. The numerical simulations with the present MS FE model, using the home-developed open-source FE solver, demonstrated potential to biomimitize the IVD and thus contribute to the advance of the knowledge on its biomechanics. |
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