Publicação
Magnetically controlled drug release system through magneto-mechanical actuation
| Resumo: | A drug release system is developed capable to modulate e drug release kinetics by the application of a magnetic field. Thus, this work reports on the production, characterization and release kinetics of a poly(L-lactic acid) (PLLA) microporous membrane containing a zeolite (Faujasite) and a magnetic stimuli-sensitive component, magnetostrictive Terfenol-D (TD), for the release of ibuprofen (IBU) as drug model. For membranes containing IBU-loaded zeolites and TD without an applied AC magnetic field, the release kinetics is characterized by a first order release. On the other hand, the application of an AC magnetic field modifies the release profile of the membrane, leading to an increase of the release rate by more than 30%, the magnetically driven release being characterized by a super case-II within the Korsmeyer-Peppas model, indicating a release mainly driven by a swelling or erosion mechanism, induced by the magnetostrictive particles under the applied magnetic field. Further, it is stated that increasing TD content above 10% w/w leads to a decrease in the IBU release, whereas increasing the HAC field increases the release performance of the developed system. |
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| Autores principais: | Barbosa, J. |
| Outros Autores: | Correia, D. M.; Gonçalves, R.; Ribeiro, Clarisse Marta Oliveira; Botelho, Gabriela; Martins, P.; Lanceros-Méndez, S. |
| Assunto: | Drug releases Magnetostrictive materials Membranes Zeolites Biomedical materials |
| Ano: | 2016 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | A drug release system is developed capable to modulate e drug release kinetics by the application of a magnetic field. Thus, this work reports on the production, characterization and release kinetics of a poly(L-lactic acid) (PLLA) microporous membrane containing a zeolite (Faujasite) and a magnetic stimuli-sensitive component, magnetostrictive Terfenol-D (TD), for the release of ibuprofen (IBU) as drug model. For membranes containing IBU-loaded zeolites and TD without an applied AC magnetic field, the release kinetics is characterized by a first order release. On the other hand, the application of an AC magnetic field modifies the release profile of the membrane, leading to an increase of the release rate by more than 30%, the magnetically driven release being characterized by a super case-II within the Korsmeyer-Peppas model, indicating a release mainly driven by a swelling or erosion mechanism, induced by the magnetostrictive particles under the applied magnetic field. Further, it is stated that increasing TD content above 10% w/w leads to a decrease in the IBU release, whereas increasing the HAC field increases the release performance of the developed system. |
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