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Preliminary evaluation of zeolite-based platforms as potential dual drug delivery systems against microbial infections in the tumor microenvironment

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Detalhes bibliográficos
Resumo:Several zeolite-based delivery systems (ZDS) built with faujasite structure were prepared containing silver (Ag+) and 5-Fluorouracil (5-FU) as antimicrobial and antineoplastic agents, respectively. The idea behind this drug combination is an answer to the increasing evidence of colonization of tumor microenvironments by pathogenic microorganisms and their active role in tumor growth. Two ZDS with a fixed load of 5-FU and different silver loads, Ag7(5-FU).
Autores principais:Bertão, Ana Raquel
Outros Autores:Ivasiv, Viktoriya; Almeida Aguiar, Cristina; Correia, Patrícia R.; Fonseca, António M.; Bañobre-López, Manuel; Baltazar, Fátima; Neves, Isabel C.
Assunto:Zeolite 5-Fluorouracil Silver Microbial infections Tumor microenvironment
Ano:2024
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:Several zeolite-based delivery systems (ZDS) built with faujasite structure were prepared containing silver (Ag+) and 5-Fluorouracil (5-FU) as antimicrobial and antineoplastic agents, respectively. The idea behind this drug combination is an answer to the increasing evidence of colonization of tumor microenvironments by pathogenic microorganisms and their active role in tumor growth. Two ZDS with a fixed load of 5-FU and different silver loads, Ag7(5-FU).