Publicação
Dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles enhances bone formation in vivo
| Resumo: | [Excerpt] Dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles, CMC/PAMAM-Dex were successfully synthesized to find applications as a controlled system of relevant molecules in Bone Tissue Engineering. These are aimed at modulatingtheproliferation anddifferentiationofstem cells,both invitro and in vivo. In previous work, we have demonstrated that CMC/ PAMAM-Dex nanoparticles are internalized with high efficiency by different cell types, namely osteoblastic-cells, SaOs-2 and rat bone marrow stromal cells, RBMSCs. The biocompatibility of HA and SPCL scaffolds was also assessed by means of seeding RBMSCs onto the materials and performing a luminescent cell viability assay, after 24 and 72hrs. [...] |
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| Autores principais: | Oliveira, J. M. |
| Outros Autores: | Sousa, R. A.; Kotobuki, N.; Malafaya, P. B.; Hirose, M.; Mano, J. F.; Reis, R. L.; Ohgushi, H. |
| Assunto: | bone Carboxymethylchitosan/poly(amidoamine) dendrimer Nanoparticles |
| Ano: | 2008 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | [Excerpt] Dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles, CMC/PAMAM-Dex were successfully synthesized to find applications as a controlled system of relevant molecules in Bone Tissue Engineering. These are aimed at modulatingtheproliferation anddifferentiationofstem cells,both invitro and in vivo. In previous work, we have demonstrated that CMC/ PAMAM-Dex nanoparticles are internalized with high efficiency by different cell types, namely osteoblastic-cells, SaOs-2 and rat bone marrow stromal cells, RBMSCs. The biocompatibility of HA and SPCL scaffolds was also assessed by means of seeding RBMSCs onto the materials and performing a luminescent cell viability assay, after 24 and 72hrs. [...] |
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