Publicação
In silico metabolic engineering: from research to the market
| Resumo: | [Excerpt] The emergence of industrial biotechnology in the last years has created the need to accelerate the tasks of strain development, as most strains have naturally evolved for growth and not for the production of desired compounds. Moreover, in many cases, microbial strains are being used to produce compounds that are not native to their metabolism, requiring the addition of heterologous genes. Thus, concurrently with fast and novel developments in molecular biology, there has been a significant investment in modelling and computational tools to aid rational strain design efforts. In our research group, we have been involved in several projects where relevant tools have been developed such as the user-friendly, widely used software tool OptFlux [1]. More recently, we have also launched the merlin tool [2] for aiding in genome-scale model reconstruction processes. [...] |
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| Autores principais: | Rocha, I. |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | [Excerpt] The emergence of industrial biotechnology in the last years has created the need to accelerate the tasks of strain development, as most strains have naturally evolved for growth and not for the production of desired compounds. Moreover, in many cases, microbial strains are being used to produce compounds that are not native to their metabolism, requiring the addition of heterologous genes. Thus, concurrently with fast and novel developments in molecular biology, there has been a significant investment in modelling and computational tools to aid rational strain design efforts. In our research group, we have been involved in several projects where relevant tools have been developed such as the user-friendly, widely used software tool OptFlux [1]. More recently, we have also launched the merlin tool [2] for aiding in genome-scale model reconstruction processes. [...] |
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