Detalhes bibliográficos
| Resumo: | Metaplastic breast carcinomas constitute a heterogeneous group of neoplasms, accounting for less than 1% of all invasive mammary carcinomas. Approximately 70-80% of metaplastic breast carcinomas overexpress the epidermal growth factor receptor (EGFR). Human epidermal growth factor receptor (HER)2 and EGFR have attracted much attention in the medical literature over the past few years owing to the fact that humanized monoclonal antibodies against HER2 and therapies directed against the extracellular ligand-binding domain or the intracellular tyrosine kinase domain of EGFR have proven successful in treating certain types of human cancer. We investigated whether HER2 and EGFR overexpression was present and evaluated gene amplification in a series of metaplastic breast carcinomas. |
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| Autores principais: | Reis-Filho, Jorge S. |
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| Outros Autores: | Milanezi, Maria Fernanda Grillo; Carvalho, Silvia; Simpson, Pete T.; Steele, Dawn; Savage, Kay; Lambros, Maryou B. K.; Pereira, Emilio M.; Nesland, Jahn M.; Lakhani, Sunil R.; Schmitt, Fernando C. |
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| Assunto: | Breast Neoplasms ErbB Receptors Female Gene Expression Profiling Humans Immunohistochemistry In Situ Hybridization Metaplasia Receptor, ErbB-2 Gene Amplification |
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| Ano: | 2005 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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