Publicação
New strategies for multimodal cancer therapy based on plasmonic lipogels
| Resumo: | Enhancing the therapeutic efficacy of chemotherapeutic agents through sequential drug delivery holds immense promise, yet current strategies are mainly dependent on the tumour microenvironment. Natural polymer-based hydrogels present suitable properties for these applications, owing to their inherent biocompatibility [1]. Herein, we present a novel strategy aimed at improving the tunability and real-time control of nanogels, as well as enabling compartmentalization of drugs for on-demand release using NIR light [2]. We hypothesized that combining chitosan/alginate nanogel with lipid-gated mesoporous silica-coated gold nanorods, thus obtaining plasmonic lipogels [3], could enable both the drug loading in different compartments and the sequential release of two chemotherapeutic drugs (doxorubicin and methotrexate). Hence, mesoporous silica-coated gold nanorods (99 ± 11 nm) were loaded with methotrexate, and further coated with a thermoresponsive phospholipid bilayer that works as gatekeeper. These particles were then incorporated in a chitosan/alginate nanogel matrix containing doxorubicin (Figure 1). The nanogels exhibited high loading efficiencies of ~90% and ~85% for methotrexate and doxorubicin, respectively. Notably, the exposure to NIR laser irradiation led to an enhanced release of both drugs, in which doxorubicin released at a faster rate than methotrexate under acidic conditions. Besides, the plasmonic nanogels were found to be cytocompatible across different cell lines. Hereby, this design strategy presents a robust and multifunctional hydrogel platform for NIR-triggered sequential delivery that holds promise for advancing cancer therapy through different drug combinations against multiple targets in tumour microenvironment. |
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| Autores principais: | Veloso, Sérgio Rafael Silva |
| Outros Autores: | Sá, Filipa Costa e; Comís-Tuche, María; Spuch, Carlos; Castanheira, Elisabete M. S. |
| Assunto: | Chitosan Alginate Plasmonic Lipogels Gold nanorods Plasmonic lipogels Drug release Photothermia Multimodal therapy |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Enhancing the therapeutic efficacy of chemotherapeutic agents through sequential drug delivery holds immense promise, yet current strategies are mainly dependent on the tumour microenvironment. Natural polymer-based hydrogels present suitable properties for these applications, owing to their inherent biocompatibility [1]. Herein, we present a novel strategy aimed at improving the tunability and real-time control of nanogels, as well as enabling compartmentalization of drugs for on-demand release using NIR light [2]. We hypothesized that combining chitosan/alginate nanogel with lipid-gated mesoporous silica-coated gold nanorods, thus obtaining plasmonic lipogels [3], could enable both the drug loading in different compartments and the sequential release of two chemotherapeutic drugs (doxorubicin and methotrexate). Hence, mesoporous silica-coated gold nanorods (99 ± 11 nm) were loaded with methotrexate, and further coated with a thermoresponsive phospholipid bilayer that works as gatekeeper. These particles were then incorporated in a chitosan/alginate nanogel matrix containing doxorubicin (Figure 1). The nanogels exhibited high loading efficiencies of ~90% and ~85% for methotrexate and doxorubicin, respectively. Notably, the exposure to NIR laser irradiation led to an enhanced release of both drugs, in which doxorubicin released at a faster rate than methotrexate under acidic conditions. Besides, the plasmonic nanogels were found to be cytocompatible across different cell lines. Hereby, this design strategy presents a robust and multifunctional hydrogel platform for NIR-triggered sequential delivery that holds promise for advancing cancer therapy through different drug combinations against multiple targets in tumour microenvironment. |
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