Publicação
Hydrogels formed by polyelectrolyte complexation
| Resumo: | This chapter provides a comprehensive look at the process of polyelectrolyte complexation, that is, electrostatic attractions between oppositely charged polymers, and its application for the assembly of biofunctional hydrogels. Polyelectrolyte attraction is a spontaneous phenomenon occurring during many homeostatic events in the human body. It is thus a biomimetic method to fabricate hydrogels. It does not use aggressive solvents and extreme temperatures, which can compromise the constructsâ biocompatibility and the bioactivity of sensitive encapsulated drugs and biologics and therefore can be classified as a green processing approach. Moreover, the polyelectrolyte complexation can be tailored and upscaled to obtain hydrogels of variable dimensions and geometriesâ from nanocoacervates to macroscopic three-dimensional networks, which turns it versatile and industrially feasible. The properties of the generated hybrid materials can be tuned in terms of molecular composition, stability, and bioactivity, which is pivotal for biomedical and tissue engineering strategies. |
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| Autores principais: | Costa, Rui R. |
| Outros Autores: | Reis, R. L.; Pashkuleva, I. |
| Assunto: | Complexation Hydrogels Polyelectrolytes Biomaterials complexes electrostatic interactions self-assembly |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | This chapter provides a comprehensive look at the process of polyelectrolyte complexation, that is, electrostatic attractions between oppositely charged polymers, and its application for the assembly of biofunctional hydrogels. Polyelectrolyte attraction is a spontaneous phenomenon occurring during many homeostatic events in the human body. It is thus a biomimetic method to fabricate hydrogels. It does not use aggressive solvents and extreme temperatures, which can compromise the constructsâ biocompatibility and the bioactivity of sensitive encapsulated drugs and biologics and therefore can be classified as a green processing approach. Moreover, the polyelectrolyte complexation can be tailored and upscaled to obtain hydrogels of variable dimensions and geometriesâ from nanocoacervates to macroscopic three-dimensional networks, which turns it versatile and industrially feasible. The properties of the generated hybrid materials can be tuned in terms of molecular composition, stability, and bioactivity, which is pivotal for biomedical and tissue engineering strategies. |
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