Publicação
Nanostructured capsules for cartilage tissue engineering
| Resumo: | Polymeric multilayered capsules (PMCs) have found great applicability in bioencapsulation, an evolving branch of tissue engineering and regenerative medicine. Here, we describe the production of hierarchical PMCs composed by an external multilayered membrane by layer-by-layer assembly of poly(L-lysine), alginate, and chitosan. The core of the PMCs is liquified and encapsulates human adipose stem cells and surface functionalized collagen II-TGF-β3 poly(L-lactic acid) microparticles for cartilage tissue engineering. |
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| Autores principais: | Correia, Clara R. |
| Outros Autores: | Reis, R. L.; Mano, J. F. |
| Assunto: | Capsules Chondrogenesis Microparticles Stem cells Bioencapsulation Capsules Cartilage regeneration Collagen II Layer-by-layer Tissue engineering TGF-β3 Bioencapsulation TGF-beta 3 |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Polymeric multilayered capsules (PMCs) have found great applicability in bioencapsulation, an evolving branch of tissue engineering and regenerative medicine. Here, we describe the production of hierarchical PMCs composed by an external multilayered membrane by layer-by-layer assembly of poly(L-lysine), alginate, and chitosan. The core of the PMCs is liquified and encapsulates human adipose stem cells and surface functionalized collagen II-TGF-β3 poly(L-lactic acid) microparticles for cartilage tissue engineering. |
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