Publicação
Benzoxazole derivatives as phototriggers for the release of butyric acid
| Resumo: | With the aim of evaluating the application of new benzoxazole derivatives as photoactive moiety in butyric acid prodrugs, ester conjugates were synthesized by reaction of the chloromethylated heterocyclic precursors with the model drug. Photocleavage studies of the conjugates in methanol/HEPES buffer (80:20) solutions at different wavelengths of irradiation (254, 300 and 350 nm) confirmed the quantitative release of the butyric acid in short irradiation times. |
|---|---|
| Autores principais: | Soares, Ana Maria Silva |
| Outros Autores: | Costa, Susana P. G.; Gonçalves, M. Sameiro T. |
| Assunto: | benzoxazole photorelease photocleavable protecting groups prodrugs butyric acid Ciências Naturais::Ciências Químicas |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | comunicação em conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | With the aim of evaluating the application of new benzoxazole derivatives as photoactive moiety in butyric acid prodrugs, ester conjugates were synthesized by reaction of the chloromethylated heterocyclic precursors with the model drug. Photocleavage studies of the conjugates in methanol/HEPES buffer (80:20) solutions at different wavelengths of irradiation (254, 300 and 350 nm) confirmed the quantitative release of the butyric acid in short irradiation times. |
|---|