Publicação

Benzoxazole derivatives as phototriggers for the release of butyric acid

Detalhes bibliográficos
Resumo:	With the aim of evaluating the application of new benzoxazole derivatives as photoactive moiety in butyric acid prodrugs, ester conjugates were synthesized by reaction of the chloromethylated heterocyclic precursors with the model drug. Photocleavage studies of the conjugates in methanol/HEPES buffer (80:20) solutions at different wavelengths of irradiation (254, 300 and 350 nm) confirmed the quantitative release of the butyric acid in short irradiation times.
Autores principais:	Soares, Ana Maria Silva
Outros Autores:	Costa, Susana P. G.; Gonçalves, M. Sameiro T.
Assunto:	benzoxazole photorelease photocleavable protecting groups prodrugs butyric acid Ciências Naturais::Ciências Químicas
Ano:	2015
País:	Portugal
Tipo de documento:	comunicação em conferência
Tipo de acesso:	acesso aberto
Instituição associada:	Universidade do Minho
Idioma:	inglês
Origem:	RepositóriUM - Universidade do Minho

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