Detalhes bibliográficos
| Resumo: | Increased glycolytic activity with accumulation of extracellular lactate is regarded as a hallmark of cancer. In lymphomas, FDG-PET has undeniable diagnostic and prognostic value, corroborating that these tumours are avid for glucose. However, the role of glycolytic metabolism-related molecules in lymphoma is not well known. Here, we aimed to evaluate the clinical and prognostic significance of a panel of glycolytic metabolism-related molecules in primary non-Hodgkin lymphomas (NHL) and to test in vitro the putative therapeutic impact of lactate transport inhibition. |
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| Autores principais: | Afonso, Julieta Alexandra Pereira |
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| Outros Autores: | Pinto, Tatiana; Sousa, Susana Patrícia Simões; Schmitt, Fernando; Longatto, Adhemar; Pinheiro, Céline; Marques, Herlander; Baltazar, Fátima |
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| Assunto: | Non-Hodgkin lymphoma Diffuse large B cell lymphoma Warburg effect Monocarboxylate transporters Metabolic symbiosis AZD3965 |
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| Ano: | 2019 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade do Minho |
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| Idioma: | inglês |
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| Origem: | RepositóriUM - Universidade do Minho |
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