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A cellular bilayered scaffolds for osteochondral tissue regeneration

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Detalhes bibliográficos
Resumo:Last decade 9.6% of the men and 18% of the woman with more than 60 years presented symptomatic Osteoarthritis [1]. Despite the progress already achieved in osteochondral (OC) repair, some limitations still needs to be overcome. A promising strategy includes a scaffold presenting two regions with different physical characteristics. The use of an acellular structure capable of recruiting the cells during the in vivo OC repair could be a faster and more efficient approach to translate into the clinics. This work aims to develop bilayered gellan gum (GG)/gellan gum-hydroxyapatite (HAp) freeze-dried scaffolds for OC regeneration.
Autores principais:Canadas, Raphael Faustino
Outros Autores:Oliveira, Joaquim M.; Marques, A. P.; Reis, R. L.
Assunto:Acellular Bilayered scaffold In vivo inflamation Osteochondral
Ano:2014
País:Portugal
Tipo de documento:outro
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:Last decade 9.6% of the men and 18% of the woman with more than 60 years presented symptomatic Osteoarthritis [1]. Despite the progress already achieved in osteochondral (OC) repair, some limitations still needs to be overcome. A promising strategy includes a scaffold presenting two regions with different physical characteristics. The use of an acellular structure capable of recruiting the cells during the in vivo OC repair could be a faster and more efficient approach to translate into the clinics. This work aims to develop bilayered gellan gum (GG)/gellan gum-hydroxyapatite (HAp) freeze-dried scaffolds for OC regeneration.