Publicação
Novel enzymes for the analysis and glycoengineering of therapeutic glycoproteins
| Resumo: | [Excerpt] Many proteins of clinical and pharmaceutical interest are N-glycosylated, being their bioactivity, pharmacokinetics and pharmacodynamics affected by the glycan structures they carry. Thus, one of the biggest challenges in the pharmaceutical and biomedical areas is the manufacturing of glycopeptides and glycoproteins with homogenous and defined oligosaccharide structures.[...] |
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| Autores principais: | Baptista, Marlene |
| Outros Autores: | Oliveira, Carla; Domingues, Lucília; Aguiar, Tatiana Quinta |
| Assunto: | Endo-ß-N-acetylglucosaminidase N-glycans Ashbya gossypii Zygosaccharomyces rouxi |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | outro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | [Excerpt] Many proteins of clinical and pharmaceutical interest are N-glycosylated, being their bioactivity, pharmacokinetics and pharmacodynamics affected by the glycan structures they carry. Thus, one of the biggest challenges in the pharmaceutical and biomedical areas is the manufacturing of glycopeptides and glycoproteins with homogenous and defined oligosaccharide structures.[...] |
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