Publicação
Magnetoliposomes as new approach for bone cancer therapies
| Resumo: | Cancer, notably osteosarcoma, poses detection and treatment challenges, with its relentless progression and resistance to conventional therapies. Innovative approaches are imperative to overcome limitations like toxicity and adverse effects on healthy cells. Nanotechnology, particularly magnetoliposomes, offers promise in this pursuit. Osteosarcoma’s intricate nature demands precision and enhanced effectiveness in treatment strategies. Conventional therapies, such as radiotherapy, often fall short of delivering optimal results due to their limitations, such as the resistance of bone cancer to radiation requiring higher doses, prompting the exploration of alternative methods. Notably, liposomes have proven to be a successful vehicle for drug delivery, significantly improving the efficacy of chemotherapeutic agents like doxorubicin. The integration of superparamagnetic nanoparticles further enhances the potential of these systems by enabling localized drug delivery. This innovative approach not only addresses the challenges associated with conventional treatments but also marks a significant stride towards improving the preci sion and overall effectiveness of combating osteosarcoma. This project involves the processing of magnetoliposomes containing encapsulated doxorubicin, magnesium, and calcium ferrites (with a diameter of 8.75 ± 0.35nm, saturation magnetization of 4.39emu/g, and Eg = 1.35eV ), along with a com prehensive study of their respective physical characteristics. The results reveal magnetoliposomes with a diameter of 542.54 ± 71.78nm and a polydispersity index of 27.48 ± 3.84%. Notably, the systems exhibit nearly complete encapsulation of doxorubicin and a magnetic nanoparticle encapsulation efficiency of 49.00±5.17%. The investigation into drug release kinetics under static and dynamic conditions unveils significant variations in release rates. Particularly, when subjected to an alternating magnetic field with dif ferent frequencies and on-cycles (time the magnetic stimuli are applied), the drug release rates are nearly 30% higher under magnetic stimulation over 5h compared to static conditions. This emphasizes how external stimuli affect controlled substance release, showcasing their potential in targeted drug delivery. |
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| Autores principais: | Barros, João Carlos Macedo |
| Assunto: | Magnetoliposomes Osteosarcoma Cancer Doxorubicin Magnetic nanoparticles Magnetic bioreactor Magnetolipossomas Osteossarcoma Cancro Doxorrubicina Nanopartículas magnéticas Biorreator magnético |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Cancer, notably osteosarcoma, poses detection and treatment challenges, with its relentless progression and resistance to conventional therapies. Innovative approaches are imperative to overcome limitations like toxicity and adverse effects on healthy cells. Nanotechnology, particularly magnetoliposomes, offers promise in this pursuit. Osteosarcoma’s intricate nature demands precision and enhanced effectiveness in treatment strategies. Conventional therapies, such as radiotherapy, often fall short of delivering optimal results due to their limitations, such as the resistance of bone cancer to radiation requiring higher doses, prompting the exploration of alternative methods. Notably, liposomes have proven to be a successful vehicle for drug delivery, significantly improving the efficacy of chemotherapeutic agents like doxorubicin. The integration of superparamagnetic nanoparticles further enhances the potential of these systems by enabling localized drug delivery. This innovative approach not only addresses the challenges associated with conventional treatments but also marks a significant stride towards improving the preci sion and overall effectiveness of combating osteosarcoma. This project involves the processing of magnetoliposomes containing encapsulated doxorubicin, magnesium, and calcium ferrites (with a diameter of 8.75 ± 0.35nm, saturation magnetization of 4.39emu/g, and Eg = 1.35eV ), along with a com prehensive study of their respective physical characteristics. The results reveal magnetoliposomes with a diameter of 542.54 ± 71.78nm and a polydispersity index of 27.48 ± 3.84%. Notably, the systems exhibit nearly complete encapsulation of doxorubicin and a magnetic nanoparticle encapsulation efficiency of 49.00±5.17%. The investigation into drug release kinetics under static and dynamic conditions unveils significant variations in release rates. Particularly, when subjected to an alternating magnetic field with dif ferent frequencies and on-cycles (time the magnetic stimuli are applied), the drug release rates are nearly 30% higher under magnetic stimulation over 5h compared to static conditions. This emphasizes how external stimuli affect controlled substance release, showcasing their potential in targeted drug delivery. |
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