Publication
Antifungal activity of phenolic compounds identified in flowers from the North Eastern Portugal against Candida species
| Summary: | Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of the North Eastern Portugal, against Candida planktonic and biofilm cells. Materials and Methods: The minimal inhibitory concentrations (MIC) were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification by colony forming units (CFUs). Results: MIC values demonstrated that gallic acid presented the highest effect against the all Candida species. Catechin showed a similar effect against C. albicans ATCC 90028cells. Additionally, gallic acid and quercetin had demonstrated only a minimum effect against Candida species biofilms. Conclusions: Gallic acid affected the growth of the different planktonic Candida species in all concentrations used, still catechin showed a similar effect against C. albicans ATCC 90028and C. glabrata ATCC 2001cells.Additionally, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms. |
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| Main Authors: | Alves, Carlos |
| Other Authors: | Ferreira, Isabel C. F. R.; Barros, Lillian; Silva, Sónia Carina; Azeredo, Joana; Henriques, Mariana |
| Subject: | antifungal effect biofilms Candida species medicinal flowers phenolic compounds |
| Year: | 2014 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Universidade do Minho |
| Language: | English |
| Origin: | RepositóriUM - Universidade do Minho |
| Summary: | Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of the North Eastern Portugal, against Candida planktonic and biofilm cells. Materials and Methods: The minimal inhibitory concentrations (MIC) were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification by colony forming units (CFUs). Results: MIC values demonstrated that gallic acid presented the highest effect against the all Candida species. Catechin showed a similar effect against C. albicans ATCC 90028cells. Additionally, gallic acid and quercetin had demonstrated only a minimum effect against Candida species biofilms. Conclusions: Gallic acid affected the growth of the different planktonic Candida species in all concentrations used, still catechin showed a similar effect against C. albicans ATCC 90028and C. glabrata ATCC 2001cells.Additionally, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms. |
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