Publicação
Advanced silk-based biotextiles for bone regeneration applications
| Resumo: | Increasing efforts have been made in tissue engineering (TE) research for novel biomaterials and scaffolds that can efficiently support bone tissue regeneration and repair. Textile-based technologies are predefined manufacturing processes of particular interest since they allow for producing finely tuned fiber-based structures with controlled three-dimensional architecture and improved mechanical properties. Highly reproducible scaffolds can be achieved with interconnected macro- and micro-porosity suitable for controlling cell functions and guiding bone tissue regeneration and repair. Herein, the recent studies dealing with the processing methodologies, physical properties, and biocompatibility of fiber-based scaffolds for bone TE applications are overviewed. The fundamentals and application of silk fibroin (SF) protein as biomaterial for scaffolds production, made up of micro- and nano-fibers are also considered. The promising outcomes of such investigations are summarized and discussed in depth. |
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| Autores principais: | Ribeiro, Viviana Pinto |
| Outros Autores: | Oliveira, J. M.; Reis, R. L. |
| Assunto: | Biotextiles Bone regeneration Silk fibroin |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | Increasing efforts have been made in tissue engineering (TE) research for novel biomaterials and scaffolds that can efficiently support bone tissue regeneration and repair. Textile-based technologies are predefined manufacturing processes of particular interest since they allow for producing finely tuned fiber-based structures with controlled three-dimensional architecture and improved mechanical properties. Highly reproducible scaffolds can be achieved with interconnected macro- and micro-porosity suitable for controlling cell functions and guiding bone tissue regeneration and repair. Herein, the recent studies dealing with the processing methodologies, physical properties, and biocompatibility of fiber-based scaffolds for bone TE applications are overviewed. The fundamentals and application of silk fibroin (SF) protein as biomaterial for scaffolds production, made up of micro- and nano-fibers are also considered. The promising outcomes of such investigations are summarized and discussed in depth. |
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