Publicação
Multi-material cellular structured orthopedic implants design: in vitro and bio-tribological performance
| Resumo: | In this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V-and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 mu m and 100 mu m, respectively. Bioactive beta-tricalcium phosphate (beta TCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to beta TCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance. |
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| Autores principais: | Costa, Ana Mafalda Meneses |
| Outros Autores: | Lima, Rui Augusto Ribeiro; Alves, N.; Silva, Nuno André Martins; Gasik, M.; Silva, Filipe Samuel; Bartolomeu, Flávio; Miranda, Maria Georgina Macedo |
| Assunto: | Multi-material structures NiTi-Based Ti6Al4V-based In vitro Bio-tribological experiments |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| Resumo: | In this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V-and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 mu m and 100 mu m, respectively. Bioactive beta-tricalcium phosphate (beta TCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to beta TCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance. |
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