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Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix

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Detalhes bibliográficos
Resumo:We sought to determine the significance of lymphatic vessel density (LVD) in pre-malignant lesions and carcinomas of the uterine cervix and to evaluate the prognostic value of lymphatic invasion and D2-40 positivity in tumor cells in the three histological types of invasive lesions. The correlation of LVD, lymphatic invasion and D2-40 positivity in tumor cells with EGFR and COX-2 expressions was also evaluated.
Autores principais:Longatto, Adhemar
Outros Autores:Pinheiro, Céline; Pereira, Sônia Maria Miranda; Etlinger, Daniela; Moreira, Marise A. R.; Jubé, Luiz Fernando; Queiroz, Geraldo Silva; Baltazar, Fátima; Schmitt, Fernando C.
Assunto:Adult Aged Antibodies, Monoclonal Antibodies, Monoclonal, Murine-Derived Antigens, Neoplasm Cervical Intraepithelial Neoplasia Cyclooxygenase 2 Epithelium ErbB Receptors Female Humans Middle Aged Prognosis Uterine Cervical Neoplasms Lymphangiogenesis Neoplasm Invasiveness D2-40 HPV Intraepithelial cervical lesions Cervical carcinoma EGFR COX-2
Ano:2007
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:We sought to determine the significance of lymphatic vessel density (LVD) in pre-malignant lesions and carcinomas of the uterine cervix and to evaluate the prognostic value of lymphatic invasion and D2-40 positivity in tumor cells in the three histological types of invasive lesions. The correlation of LVD, lymphatic invasion and D2-40 positivity in tumor cells with EGFR and COX-2 expressions was also evaluated.